ZM 449829,JAK3抑制剂(ab145881)
Key features and details
- Potent, selective, ATP-competitive JAK3 inhibitor. Potent transglutaminase inhibitor.
- CAS Number: 4452-06-6
- Purity: > 98%
- Soluble in DMSO and in ethanol
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
ZM 449829,JAK3抑制剂 -
描述
Potent,selective,ATP-competitive JAK3抑制剂. Potent transglutaminase抑制剂. -
生物学描述
Potent, selective, ATP-competitive JAK3 inhibitor (pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively). Potent transglutaminase inhibitor (IC50 = 10 nM). Inhibits STAT5 phosphorylation and T cell proliferation. -
纯度
> 98% -
CAS编号
4452-06-6 -
化学结构
性能
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化学名称
1-(2-Naphthalenyl)-2-propen-1-one -
分子量
182.22 -
分子式
C13H10O -
PubChem识别号
3799 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO and in ethanol -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C=CC(=O)C1=CC2=CC=CC=C2C=C1 -
来源
Synthetic
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研究领域
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab145881 尚未被引用在任何文献中。