ZD7288,Sino-atrial node function modulator (ab120102)
Key features and details
- Sino-atrial node function modulator
- CAS Number: 133059-99-1
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
ZD7288,Sino-atrial node function modulator -
描述
Sino-atrial node function modulator -
别名
- ICI D7288
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生物学描述
Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
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CAS编号
133059-99-1 -
化学结构
性能
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化学名称
4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride -
分子量
292.81 -
分子式
C15H21ClN4 -
PubChem识别号
123983 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Cl-].C[n+]1c(NC)cc(nc1C)N(CC)c2ccccc2 -
来源
Synthetic
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研究领域
图片
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2D chemical structure image of ab120102, ZD7288, Sino-atrial node function modulator
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Membrane currents during slow voltage ramps from ?120 mV to ?40 mV in the presence of TTX (0.5 µM) and ZD7288 (50 µM), and during subsequent bath application of CCh (light grey line; 50 µM; B1) show that cholinergic receptor activation induces an inward current at voltages near resting membrane potential that reverses around ?76 mV, consistent the blockade of outward K+ currents. The application of CCh occluded additional inward current during subsequent bath application of XE-991 (dark grey line; 10 µM) sµggesting that CCh depolarizes PaS neurons in part by suppression of the M-current. Current subtractions show that CCh blocks an outward current that reverses at ?83.3±7.0 mV (black line; B2), and also occluded membrane currents normally induced by XE-991 (grey line).
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (24)
ab120102 被引用在 24 文献中.
- Ma Q et al. Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia. Proc Natl Acad Sci U S A 120:e2207003120 (2023). PubMed: 36812204
- Wei XP et al. A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing. Neuron 110:644-657.e6 (2022). PubMed: 34998469
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Fei F et al. Discrete subicular circuits control generalization of hippocampal seizures. Nat Commun 13:5010 (2022). PubMed: 36008421
- Zhang J et al. Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice. Cell Rep 36:109495 (2021). PubMed: 34348148