Wortmannin,PI3-kinase抑制剂(ab120148)
Key features and details
- PI3-kinase inhibitor
- CAS Number: 19545-26-7
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Penicillium funiculosum
概述
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产品名称
Wortmannin,PI3-kinase抑制剂 -
描述
PI3-kinase抑制剂 -
生物学描述
Potent, selective and cell-permeable inhibitor of phosphatidylinositol-3-kinase (PI3-kinase) (IC50 ~ 3 nM)
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纯度
> 98% -
CAS编号
19545-26-7 -
化学结构
性能
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化学名称
(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,h]-2-h]-2-benzopyran-3,6,9-trione -
分子量
428.44 -
分子式
C23H24O8 -
PubChem识别号
312145 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 50 mM and in ethanol to 5 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)O[C@@H]4C[C@]5(C)C(=O)CC[C@H]5C=3C(=O)c2occ1C(=O)O[C@H](COC)[C@@](C)(c12)C=34 -
来源
Penicillium funiculosum
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研究领域
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Signal transduction
- PI3K/Akt signaling
- PI3-kinase
- Inhibitors
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (15)
ab120148 被引用在 15 文献中.
- Zhang MH & Liu J Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway. Bioengineered 13:10047-10060 (2022). PubMed: 35412944
- Lee JH et al. n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway. Int J Mol Sci 22:N/A (2021). PubMed: 34199295
- Chen S et al. Ginsenoside metabolite 20(S)-protopanaxadiol promotes neural stem cell transition from a state of proliferation to differentiation by inducing autophagy and cell cycle arrest. Mol Med Rep 22:353-361 (2020). PubMed: 32319663
- Martin-Gallausiaux C et al. Fusobacterium nucleatum Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity via FomA and TLR2. Front Immunol 11:583644 (2020). PubMed: 33408714
- Gamero-Estevez E et al. Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31581662