Wiskostatin,N-WASP抑制剂(ab141085)
Key features and details
- Selective N-WASP inhibitor
- CAS Number: 253449-04-6
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Wiskostatin,N-WASP抑制剂 -
描述
Selective N-WASP抑制剂 -
生物学描述
Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
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纯度
> 99% -
CAS编号
253449-04-6 -
化学结构
性能
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化学名称
3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol -
分子量
426.15 -
分子式
C17H18Br2N2O -
PubChem识别号
2775510 -
存放说明
Store at +4°C. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CC(O)Cn3c1ccc(Br)cc1c2cc(Br)ccc23 -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (4)
ab141085 被引用在 4 文献中.
- Hua R et al. Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes. J Cell Physiol 238:1063-1079 (2023). PubMed: 36924084
- Hasegawa K et al. N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo. Development 149:N/A (2022). PubMed: 36469048
- Soykan T et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93:854-866.e4 (2017). PubMed: 28231467
- Baranov MV et al. Podosomes of dendritic cells facilitate antigen sampling. J Cell Sci 127:1052-64 (2014). PubMed: 24424029