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There are many different types of extracellular vesicles (EVs). Different subpopulations of exosomes, microvesicles and apoptotic bodies have been found to vary in size, composition and intracellular origin.
Within the last decade, cell-secreted EVs have been isolated from most of the fluids of the body, with many laboratories from around the world showing that their composition of lipids, proteins, messenger and micro RNAs are cell-type specific and subject to changes in pathological scenarios. As a result, EVs have been widely studied as a biological source to unravel low invasive biomarkers for predicting, diagnosing and monitoring diseases.
However, despite the many technological advances for the isolation of and analysis of EVs, there is still a lack of resources for transferring the basic knowledge acquired into useful clinical data.
Within this webinar, we will review:
Dr. Juan Manuel Falcón is a Principal Investigator in the CIC bioGUNE research institute (Spain), where he leads the EXOSOMES laboratory and the METABOLOMICS platform of the center. He is a cell biologist with wide experience in performing high-content omics-based analyses.
During his PhD at the Biomedical Research Institute "Alberto Sols" in Madrid, Dr. Falcon carried out an extensive biochemical analysis of the Ycf1 carrier of S. cerevisiae, as a model for the study of the CFTR protein that is responsible for Cystic Fibrosis (CF) within humans. As a postdoctoral fellow in the Universidad Autonoma de Madrid, he participated in the generation of the knockout mouse for the POMT1 gene codifying the O-mannosyltransferase protein 1, an essential enzyme in development, with implications in muscular dystrophies. As a postdoctoral researcher in the Human Genetics Department of University of California, Los Angeles (UCLA, USA), he focused on the biochemical and functional characterization of proteins associated with the Hermansky-Pudlak syndrome (HPS), which causes defects in the formation of specialized organelles named lysosome-related organelles (e.g. melanosomes, platelet dense granules), by using mice and flies as model organisms.
In 2006, Juan moved to CIC bioGUNE and started his research on extracellular vesicles (EVs)as a source for disease biomarker discovery and a tool for therapeutic applications. Dr. Falcon´s group has characterized exosomes secreted by many in vivo and in vitro experimental models of several diseases, as well as from different bodily fluids- participating in more than 25 publications related with extracellular vesicles.
He is a co-founder of the Spanish Association for Innovation and Investigation on Extracellular Vesicles (GEIVEX), forms part of the Spanish Network of Excellence in Exosomes (REDIex), and is a member of the ISEV and part of the management committee of the European Network to study Microvesicles and Exosomes in Health and Disease (Me-Had).
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