Anti-WBSCR22抗体(ab97911)
Key features and details
- Rabbit polyclonal to WBSCR22
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-WBSCR22抗体 -
描述
兔多克隆抗体to WBSCR22 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment, corresponding to a sequence within amino acids 1-233 of Human WBSCR22 (NP_059998).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab97911于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/250. The staining pattern is dependent on the antibody titer and nature of the biology. Proliferating tumor cells might be positive for nuclear staining while the differentiated cells show no nuclear staining. Antibody titer and antigen retrieval time should be adjusted.
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WB |
1/500 - 1/3000. Predicted molecular weight: 32 kDa.
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说明 |
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IHC-P
1/100 - 1/250. The staining pattern is dependent on the antibody titer and nature of the biology. Proliferating tumor cells might be positive for nuclear staining while the differentiated cells show no nuclear staining. Antibody titer and antigen retrieval time should be adjusted. |
WB
1/500 - 1/3000. Predicted molecular weight: 32 kDa. |
靶标
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功能
Methyltransferase that may act on DNA. -
组织特异性
Strongly expressed in heart, skeletal muscle and kidney. Also expressed in spleen, liver, lung and testis. -
疾病相关
Note=WBSCR22 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR22 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. -
序列相似性
Belongs to the methyltransferase superfamily. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 114049 Human
- SwissProt: O43709 Human
- Unigene: 647063 Human
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别名
- HASJ4442 antibody
- HUSSY 3 antibody
- HUSSY3 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab97911 被引用在 3 文献中.
- Garcia BCB et al. BUD23-TRMT112 interacts with the L protein of Borna disease virus and mediates the chromosomal tethering of viral ribonucleoproteins. Microbiol Immunol 65:492-504 (2021). PubMed: 34324219
- Zorbas C et al. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Mol Biol Cell 26:2080-95 (2015). WB . PubMed: 25851604
- Ounap K et al. The Human WBSCR22 Protein Is Involved in the Biogenesis of the 40S Ribosomal Subunits in Mammalian Cells. PLoS One 8:e75686 (2013). ICC/IF ; Human . PubMed: 24086612