Anti-VAMP8/EDB抗体(ab6186)
Key features and details
- Rabbit polyclonal to VAMP8/EDB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-VAMP8/EDB抗体
参阅全部 VAMP8/EDB 一抗 -
描述
兔多克隆抗体to VAMP8/EDB -
宿主
Rabbit -
特异性
Reacts specifically with the 10 kDa protein of human CaCo-2, rat PC12 and dog MDCK cell extracts. -
种属反应性
与反应: Human
预测可用于: Dog -
免疫原
Synthetic peptide corresponding to Human VAMP8/EDB.
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常规说明
Previously labelled as VAMP8.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
IM: Use at an assay dependant dilution.
IP: Use at an assay dependant dilution.
WB: 1/200 - 1/1000.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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功能
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. -
组织特异性
Platelets. -
序列相似性
Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 8673 Human
- Omim: 603177 Human
- SwissProt: Q9BV40 Human
- Unigene: 714302 Human
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别名
- EDB antibody
- Endobrevin antibody
- VAMP 8 antibody
see all
实验方案
数据表及文件
文献 (7)
ab6186 被引用在 7 文献中.
- Yang Y et al. Polyphenols differentially inhibit degranulation of distinct subsets of vesicles in mast cells by specific interaction with granule-type-dependent SNARE complexes. Biochem J 450:537-46 (2013). PubMed: 23252429
- Bethani I et al. Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking. Traffic 10:1543-59 (2009). WB . PubMed: 19624487
- Mashima H et al. Involvement of vesicle-associated membrane protein 7 in human gastric epithelial cell vacuolation induced by Helicobacter pylori-produced VacA. Infect Immun 76:2296-303 (2008). PubMed: 18362137
- Lapierre LA et al. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol 292:G1249-62 (2007). WB, IHC-P, IF ; Human . PubMed: 17255364
- Boström P et al. SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat Cell Biol 9:1286-93 (2007). PubMed: 17922004
- Pooley RD et al. CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25. Mol Biol Cell 17:3176-86 (2006). PubMed: 16672379
- Polgár J et al. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Blood 100:1081-3 (2002). WB ; Human . PubMed: 12130530