概述

  • 产品名称
  • 描述
    兔多克隆抗体to UCP3
  • 宿主
    Rabbit
  • 经测试应用
    适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment corresponding to Human UCP3 aa 1-110.
    Sequence:

    MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAV QTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYD SVKQVYTPKG


    Database link: P55916

  • 阳性对照
    • Mouse testis, mouse liver and mouse lung cell line extracts.

性能

应用

Our Abpromise guarantee covers the use of ab180643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 34 kDa.
IHC-P 1/50 - 1/200.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能
    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
  • 组织特异性
    Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles.
  • 疾病相关
    Defects in UCP3 may be involved in obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • 序列相似性
    Belongs to the mitochondrial carrier family.
    Contains 3 Solcar repeats.
  • 细胞定位
    Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
  • 形式
    UCP3 is preferentially expressed in muscle
  • 别名
    • Mitochondrial uncoupling protein 3 antibody
    • SLC25A9 antibody
    • Solute carrier family 25 member 9 antibody
    • UCP 3 antibody
    • UCP3 antibody
    • UCP3_HUMAN antibody
    • Uncoupling protein 3 antibody
    • Uncoupling protein 3 mitochondrial proton carrier antibody
    see all

图片

  • Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab180643. Blue DAPI for nuclear staining.
  • All lanes : Anti-UCP3 antibody (ab180643) at 1/500 dilution

    Lane 1 : mouse testis cell line extract
    Lane 2 : mouse liver cell line extract
    Lane 3 : mouse lung cell line extract

    Predicted band size: 34 kDa

文献

ab180643 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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