Key features and details
- Rabbit polyclonal to TRAP/CD40L
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
参阅全部 TRAP/CD40L 一抗
经测试应用适用于: WBmore details
种属反应性与反应: Mouse, Rat, Human
Synthetic peptide corresponding to Human TRAP/CD40L. surrounding amino acid 246 of human CD40 Ligand
Database link: P29965
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
存储溶液Preservative: 0.03% Proclin 300
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.015% EDTA
Concentration information loading...
纯度Immunogen affinity purified
功能Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
组织特异性Specifically expressed on activated CD4+ T-lymphocytes.
疾病相关Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
序列相似性Belongs to the tumor necrosis factor family.
翻译后修饰The soluble form derives from the membrane form by proteolytic processing.
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
细胞定位Secreted and Cell membrane.
- Information by UniProt
- CD 40L antibody
- CD154 antibody
- CD40 antigen ligand antibody
ab2391 被引用在 11 文献中.
- Li GQ et al. MicroRNA-21 from bone marrow mesenchymal stem cell-derived extracellular vesicles targets TET1 to suppress KLF4 and alleviate rheumatoid arthritis. Ther Adv Chronic Dis 12:20406223211007369 (2021). PubMed: 33995992
- Carriba P & Davies AM How CD40L reverse signaling regulates axon and dendrite growth. Cell Mol Life Sci N/A:N/A (2020). PubMed: 32506167
- Huang Y et al. STIM1 controls calcineurin/Akt/mTOR/NFATC2-mediated osteoclastogenesis induced by RANKL/M-CSF. Exp Ther Med 20:736-747 (2020). PubMed: 32742319
- Chei S et al. Dysfunction of B Cell Leading to Failure of Immunoglobulin Response Is Ameliorated by Dietary Silk Peptide in 14-Month-Old C57BL/6 Mice. Front Nutr 7:583186 (2020). PubMed: 33330583
- Calhan OY et al. CD40L reverse signaling suppresses prevertebral sympathetic axon growth and tissue innervation. Dev Neurobiol 79:949-962 (2019). PubMed: 32077240