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Cell Biology Apoptosis Intracellular Associated Proteins
使用敲除细胞株进行验证重组RabMAb

重组Anti-TRAF2抗体[EPR6048] (ab126758)

  • Datasheet
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Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Flow Cytometry - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Immunocytochemistry/ Immunofluorescence - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Immunoprecipitation - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Flow Cytometry - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Immunocytochemistry/ Immunofluorescence - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • OI-RD Scanning - Anti-TRAF2 antibody [EPR6048] (ab126758)
  • Anti-TRAF2 antibody [EPR6048] (ab126758)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR6048] to TRAF2
  • Suitable for: WB, IP, IHC-P, Flow Cyt, ICC/IF
  • Knockout validated
  • Reacts with: Rat, Human

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概述

  • 产品名称

    Anti-TRAF2抗体[EPR6048]
    参阅全部 TRAF2 一抗
  • 描述

    兔单克隆抗体[EPR6048] to TRAF2
  • 宿主

    Rabbit
  • Tested Applications & Species

    Application Species
    Flow Cyt
    Human
    ICC/IF
    Human
    IHC-P
    Human
    IP
    Human
    WB
    Rat
    Human
    See all applications and species data
  • 免疫原

    Synthetic peptide within Human TRAF2 aa 1-100 (N terminal). The exact sequence is proprietary.

  • 阳性对照

    • WB: HEK-293T, PC12, MOLT4, HeLa, and 293T cell lysates. ICC: HeLa cells. IHC-P: Human kidney tissue. Flow Cyt: HeLa cells.
  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C.
  • 解离常数(KD)

    KD = 1.70 x 10 -12 M
    Learn more about KD
  • 存储溶液

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 40% Glycerol, 59% PBS, 0.05% BSA
  • Concentration information loading...
  • 纯度

    Protein A purified
  • 克隆

    单克隆
  • 克隆编号

    EPR6048
  • 同种型

    IgG
  • 研究领域

    • Cell Biology
    • Apoptosis
    • Intracellular
    • Associated Proteins
    • Signal Transduction
    • Adapters
    • Cytoplasmic
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • NFkB Pathway
    • Signal Transduction
    • Growth Factors/Hormones
    • TNF
    • Cancer
    • Growth factors
    • TNF
    • Cancer
    • Signal transduction
    • Other
    • Cardiovascular
    • Atherosclerosis
    • Vascular Inflammation
    • Inflammatory mediators

相关产品

  • Alternative Versions

    • Alexa Fluor® 488 Anti-TRAF2 antibody [EPR6048] (ab198971)
    • PE Anti-TRAF2 antibody [EPR6048] (ab213667)
    • Alexa Fluor® 594 Anti-TRAF2 antibody [EPR6048] (ab215491)
    • Anti-TRAF2 antibody [EPR6048] - BSA and Azide free (ab230795)
  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed (ab216773)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • KO cell lines

    • Human TRAF2 knockout HEK-293T cell line (ab266060)
  • KO cell lysates

    • Human TRAF2 knockout HEK-293T cell lysate (ab257759)
  • KO cell pellets

    • Human TRAF2 knockout HEK293T cell pellet (ab278906)
  • Positive Controls

    • PC-12 cytoplasmic extract lysate (ab14883)
  • Recombinant Protein

    • Recombinant Human TRAF2 protein (ab204091)

应用

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab126758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

应用 Species
Flow Cyt
Human
ICC/IF
Human
IHC-P
Human
IP
Human
WB
Rat
Human
All applications
Mouse
应用 Ab评论 说明
WB
1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 55 kDa).
IP
1/40.
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

See IHC antigen retrieval protocols.

Flow Cyt
1/120.

For unpurified, use 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

ICC/IF
1/100.
说明
WB
1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 55 kDa).
IP
1/40.
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

See IHC antigen retrieval protocols.

Flow Cyt
1/120.

For unpurified, use 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

ICC/IF
1/100.

靶标

  • 功能

    Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.
  • 通路

    Protein modification; protein ubiquitination.
  • 序列相似性

    Belongs to the TNF receptor-associated factor family. A subfamily.
    Contains 1 MATH domain.
    Contains 1 RING-type zinc finger.
    Contains 2 TRAF-type zinc fingers.
  • 结构域

    The coiled coil domain mediates homo- and hetero-oligomerization.
    The MATH/TRAF domain binds to receptor cytoplasmic domains.
    The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling.
  • 翻译后修饰

    Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linked polyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B.
    Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via 'Lys-48'-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains.
  • 细胞定位

    Cytoplasm.
  • Target information above from: UniProt accession Q12933 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 7186 Human
    • Entrez Gene: 22030 Mouse
    • Entrez Gene: 311786 Rat
    • Omim: 601895 Human
    • SwissProt: Q12933 Human
    • SwissProt: P39429 Mouse
    • Unigene: 522506 Human
    • Unigene: 3399 Mouse
    • Unigene: 105232 Rat
    see all
  • 别名

    • E3 ubiquitin-protein ligase TRAF2 antibody
    • MGC:45012 antibody
    • OTTHUMP00000022625 antibody
    • OTTHUMP00000064745 antibody
    • TNF receptor associated factor 2 antibody
    • TNF receptor-associated factor 2 antibody
    • TNF receptor-associated protein antibody
    • TRAF 2 antibody
    • TRAF2 antibody
    • TRAF2_HUMAN antibody
    • TRAP 3 antibody
    • TRAP antibody
    • TRAP3 antibody
    • Tumor necrosis factor type 2 receptor associated protein 3 antibody
    • Tumor necrosis factor type 2 receptor-associated protein 3 antibody
    see all

图片

  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    All lanes : Anti-TRAF2 antibody [EPR6048] (ab126758) at 1/1000 dilution

    Lane 1 : Wild-type HEK-293T cell lysate
    Lane 2 : TRAF2 knockout HEK-293T cell lysate

    Lysates/proteins at 20 µg per lane.

    Performed under reducing conditions.

    Predicted band size: 55 kDa
    Observed band size: 55 kDa



    Lanes 1- 2: Merged signal (red and green). Green - ab126758 observed at 55 kDa. Red - Anti-GAPDH antibody [6C5] - Loading Control (ab8245) observed at 37 kDa.

     ab126758 was shown to react with TRAF2 in wild-type HEK-293T cells in western blot. Loss of signal was observed when knockout cell line ab266060 (knockout cell lysate ab257759) was used. Wild-type HEK-293T and TRAF2 knockout HEK-293T cell lysates were subjected to SDS-PAGE. Membrane was blocked for 1 hour at room temperature in 0.1% TBST with 3% non-fat dried milk. ab126758 and Anti-GAPDH antibody [6C5] - Loading Control (ab8245) overnight at 4°C at a 1 in 1000 dilution and a 1 in 20000 dilution respectively. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye®800CW) preadsorbed (ab216773) and Goat anti-Mouse IgG H&L (IRDye®680RD) preadsorbed (ab216776) secondary antibodies at 1 in 20000 dilution for 1 hour at room temperature before imaging.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Immunohistochemical staining of paraffin embedded human cervical cancer with purified ab126758 at a working dilution of 1/100. The secondary antibody used is ab97051, a HRP-conjugated goat anti-rabbit IgG (H+L), at a dilution of 1/500. The sample is counter-stained with hematoxylin. Antigen retrieval was perfomed using Tris-EDTA buffer, pH 9.0. PBS was used instead of the primary antibody as the negative control, and is shown in the inset.
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Lane 1: Wild-type HAP1 cell lysate (20 µg)
    Lane 2: TRAF2 knockout HAP1 cell lysate (20 µg)
    Lane 3: Human skeletal muscle lysate (20 µg)
    Lane 4: U2OS cell lysate (20 µg)
    Lanes 1 - 4: Merged signal (red and green). Green - ab126758 observed at 55 kDa. Red - loading control, ab8245, observed at 37 kDa.

    ab126758 was shown to specifically react with TRAF2 when TRAF2 knockout samples were used. Wild-type and TRAF2 knockout samples were subjected to SDS-PAGE. ab126758 and ab8245 (loading control to GAPDH) were diluted 1/1000 and 1/2000 respectively and incubated overnight at 4°C. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed (ab216773) and Goat anti-Mouse IgG H&L (IRDye® 680RD) preadsorbed (ab216776) secondary antibodies at 1/10000 dilution for 1 h at room temperature before imaging.

  • Flow Cytometry - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Flow Cytometry - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Overlay histogram showing HeLa cells fixed in 2% PFA and stained with purified ab126758 at a dilution of 1 in 120 (red line). The secondary antibody used was FITC goat anti-rabbit at a dilution of 1 in 150. Rabbit monoclonal IgG was used as an isotype control (black) and cells without antibody were used as a negative control (blue).
  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    All lanes : Anti-TRAF2 antibody [EPR6048] (ab126758) at 1/2000 dilution (purified)

    Lane 1 : Molt-4 cell lysate
    Lane 2 : HeLa cell lysate
    Lane 3 : HEK293 cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    All lanes : HRP goat anti-rabbit (H+L) at 1/1000 dilution

    Predicted band size: 55 kDa
    Observed band size: 53 kDa
    why is the actual band size different from the predicted?



    Blocking buffer: 5% NFDM/TBST

    Dilution buffer: 5% NFDM/TBST

  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Blocking buffer: 5% NFDM/TBST

    Dilution buffer: 5% NFDM/TBST

  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Blocking buffer: 5% NFDM/TBST

    Dilution buffer: 5% NFDM/TBST

  • Immunocytochemistry/ Immunofluorescence - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Immunocytochemistry/ Immunofluorescence - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Immunofluorescence staining of HeLa cells with purified ab126758 at a working dilution of 1 in 100, counter-stained with DAPI. Tubulin was stained with mouse anti-tubulin at a dilution of 1/1000 (ab7291) and Alexa Fluor® 594 goat anti-mouse at a dilution of 1/500 (ab150120) . The secondary antibody was ab150077 Alexa Fluor® 488 goat anti rabbit, used at a dilution of 1 in 500. The cells were fixed in 4% PFA and permeabilized using 0.1% Triton X 100. The negative controls are shown in the bottom middle and right hand panels - for the first negative control, purified ab126758 was used at a dilution of 1/200 followed by an Alexa Fluor® 555 goat anti-mouse antibody at a dilution of 1/500 and for the second negative control mouse primary antibody (ab7291) and anti-rabbit secondary antibody (ab15007) were used.

  • Immunoprecipitation - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Immunoprecipitation - Anti-TRAF2 antibody [EPR6048] (ab126758)
    ab126758 (purified) at 1/40 immunoprecipitating TRAF2 in HEK293 (Lane 1 and 2). Lane 3 - PBS. For western blotting a HRP-conjugated anti-rabbit IgG specific to the non-reduced form of IgG was used as the secondary antibody (1/1500). Blocking buffer and concentration: 5% NFDM/TBST. Diluting buffer and concentration: 5% NFDM /TBST.
  • Flow Cytometry - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Flow Cytometry - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Overlay histogram showing HeLa cells stained with unpurified ab126758 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (unpurified ab126758, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

  • Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Western blot - Anti-TRAF2 antibody [EPR6048] (ab126758)
    All lanes : Anti-TRAF2 antibody [EPR6048] (ab126758) at 1/1000 dilution (unpurified)

    Lane 1 : PC12 cell lysate
    Lane 2 : MOLT4 cell lysate
    Lane 3 : HeLa cell lysate
    Lane 4 : 293T cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : HRP-conjugated goat anti-rabbit at 1/2000 dilution

    Predicted band size: 55 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Unpurified ab126758, at 1/50 dilution, staining TRAF2 in paraffin-embedded Human kidney tissue, by Immunohistochemistry.

    Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

  • Immunocytochemistry/ Immunofluorescence - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Immunocytochemistry/ Immunofluorescence - Anti-TRAF2 antibody [EPR6048] (ab126758)

    Unpurified ab126758, at 1/100 dilution, staining TRAF2 in HeLa cells, by Immunofluorescence.

  • OI-RD Scanning - Anti-TRAF2 antibody [EPR6048] (ab126758)
    OI-RD Scanning - Anti-TRAF2 antibody [EPR6048] (ab126758)
    Equilibrium disassociation constant (KD)
    Learn more about KD

    Click here to learn more about KD
  • Anti-TRAF2 antibody [EPR6048] (ab126758)
    Anti-TRAF2 antibody [EPR6048] (ab126758)

实验方案

  • Flow cytometry protocols
  • Immunoprecipitation protocols
  • Immunohistochemistry protocols
  • Immunocytochemistry & immunofluorescence protocols
  • Western blot protocols

Click here to view the general protocols

数据表及文件

    • Datasheet
  • 文献 (9)

    发表研究结果有使用 ab126758?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab126758 被引用在 9 文献中.

    • Li Z  et al. Changes in the circRNA expression profile of PC12 cells induced by TDCIPP exposure may regulate the downstream NF-?B pathway via the Traf2 gene. Chemosphere 254:126834 (2020). PubMed: 32339792
    • Vredevoogd DW  et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell 178:585-599.e15 (2019). PubMed: 31303383
    • Yang L  et al. Jiang-Zhi granules decrease sensitivity to low-dose CCl4 induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress. BMC Complement Altern Med 19:228 (2019). PubMed: 31438932
    • Yue LJ  et al. S-allyl-cysteine sulfoxide (alliin) alleviates myocardial infarction by modulating cardiomyocyte necroptosis and autophagy. Int J Mol Med 44:1943-1951 (2019). PubMed: 31573046
    • Zhang C  et al. Activation of TNF-a/NF-?B axis enhances CRL4BDCAF11E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells. Mol Oncol N/A:N/A (2018). WB . PubMed: 29377600
    • Sikorski K  et al. A high-throughput pipeline for validation of antibodies. Nat Methods 15:909-912 (2018). PubMed: 30377371
    • Yu R  et al. Kruppel-like factor 4 inhibits non-small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-ß1-meidated ERK/JNK/NF-?B signaling pathways. Tumour Biol 39:1010428317705574 (2017). PubMed: 28631556
    • Su X  et al. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep 5:18588 (2015). PubMed: 26687459
    • Guicciardi ME  et al. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One 9:e92124 (2014). PubMed: 24633224

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    研究类别(A-Z)
    • 肿瘤研究
    • 心血管研究
    • 细胞生物学
    • 发育生物学
    • 染色质及细胞核信号转导研究
    • 免疫学
    • 代谢
    • 微生物学
    • 神经生物学
    • 信号转导研究
    • 干细胞研究
    产品种类(A-Z)
    • 一抗
    • 二抗
    • 生化试剂
    • 亚类对照
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    • 试剂盒
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    • 细胞裂解液
    • 多肽
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