Key features and details
- Rat monoclonal [HM102] to TNF Receptor II
- Reacts with: Mouse
- Isotype: IgG2a
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
产品名称Anti-TNF Receptor II抗体[HM102]
参阅全部 TNF Receptor II 一抗
描述大鼠单克隆抗体[HM102] to TNF Receptor II
特异性Mouse TNF-R II and the soluble receptor.
表位Extra-cellular part of the receptor.
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
存储溶液Preservative: 0.1% Sodium azide
Constituent: 1% BSA
Concentration information loading...
纯度Protein G purified
Furthermore it can be used for immunoprecipitation and histology on frozen sections.
The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-?.
功能Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
序列相似性Contains 4 TNFR-Cys repeats.
翻译后修饰Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
细胞定位Secreted and Cell membrane.
- Information by UniProt
- CD120b antibody
- p75 antibody
- p75 TNF receptor antibody
ab7369 被引用在 2 文献中.
- Fu XQ et al. Tumor necrosis factor alpha mediates neuromuscular synapse elimination. Cell Discov 6:9 (2020). PubMed: 32140252
- Tesz GJ et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . PubMed: 17500068