Anti-TNF Receptor I抗体(ab90463)
Key features and details
- Rabbit polyclonal to TNF Receptor I
- Suitable for: WB
- Reacts with: Human, Saccharomyces cerevisiae
- Isotype: IgG
概述
-
产品名称
Anti-TNF Receptor I抗体
参阅全部 TNF Receptor I 一抗 -
描述
兔多克隆抗体to TNF Receptor I -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human, Saccharomyces cerevisiae -
免疫原
Synthetic peptide derived from the sequence of mouse TNF Receptor 1
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab90463于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
说明 |
---|
WB (ECL): 1/1000. Predicted molecular weight: 51 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
-
功能
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. -
疾病相关
Familial hibernian fever
Multiple sclerosis 5 -
序列相似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
结构域
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
翻译后修饰
The soluble form is produced from the membrane form by proteolytic processing. -
细胞定位
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. - Information by UniProt
-
数据库链接
- Entrez Gene: 7132 Human
- Omim: 191190 Human
- SwissProt: P19438 Human
- Unigene: 279594 Human
- Unigene: 713833 Human
-
别名
- CD120a antibody
- FPF antibody
- MGC19588 antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab90463 被引用在 5 文献中.
- Li Q et al. TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway. J Neuroinflammation 18:271 (2021). PubMed: 34789280
- Duan Z et al. Inhibition of microRNA-155 Reduces Neuropathic Pain During Chemotherapeutic Bortezomib via Engagement of Neuroinflammation. Front Oncol 10:416 (2020). PubMed: 32296644
- You L et al. Overexpression of miR-29a-3p Suppresses Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells in Atherosclerosis via Targeting TNFRSF1A. Biomed Res Int 2020:9627974 (2020). PubMed: 32964047
- Li C et al. Blocking TRPA1 and TNF-a Signal Improves Bortezomib-Induced Neuropathic Pain. Cell Physiol Biochem 51:2098-2110 (2018). PubMed: 30522101
- Zhou Z et al. Inhibition of Epithelial TNF-a Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis. Front Immunol 8:1468 (2017). PubMed: 29176974