Anti-LTA抗体(ab227929)
Key features and details
- Rabbit polyclonal to TNF beta
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-LTA抗体
参阅全部 TNF beta 一抗 -
描述
兔多克隆抗体to TNF beta -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat, Human
预测可用于: Chimpanzee, Rhesus monkey -
免疫原
Recombinant fragment within Human LTA (internal sequence). The exact sequence is proprietary.
Database link: P01374 -
阳性对照
- WB: Rat and human spleen tissue extracts.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab227929于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 22 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 22 kDa. |
靶标
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功能
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. -
疾病相关
Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). -
序列相似性
Belongs to the tumor necrosis factor family. -
细胞定位
Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated. - Information by UniProt
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数据库链接
- Entrez Gene: 494185 Chimpanzee
- Entrez Gene: 4049 Human
- Entrez Gene: 25008 Rat
- Entrez Gene: 715425 Rhesus monkey
- Omim: 153440 Human
- SwissProt: P61125 Chimpanzee
- SwissProt: P01374 Human
- SwissProt: Q06332 Rat
see all -
别名
- LTalpha antibody
- DAMA-25N12.13-004 antibody
- DIF antibody
see all
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab227929 被引用在 1 文献中.
- Zhou L et al. Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1ß-Induced Inflammation in Osteoarthritis Chondrocytes. Cell J 23:485-494 (2021). PubMed: 34455725