Anti-TNF alpha抗体(ab9635)
Key features and details
- Rabbit polyclonal to TNF alpha
- Suitable for: Sandwich ELISA
- Reacts with: Recombinant fragment
- Isotype: IgG
概述
-
产品名称
Anti-TNF alpha抗体
参阅全部 TNF alpha 一抗 -
描述
兔多克隆抗体to TNF alpha -
宿主
Rabbit -
经测试应用
适用于: Sandwich ELISAmore details -
种属反应性
与反应: Recombinant fragment -
免疫原
Recombinant fragment within Human TNF alpha aa 50 to the C-terminus. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. E.coli derived Recombinant Human TNF-alpha
Database link: P01375 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Lyophilized:Reconstitute with 200µl of sterile water. -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
No preservative, sterile filtered -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
轻链类型
unknown -
研究领域
相关产品
-
ELISA pair antibody
-
Isotype control
-
Positive Controls
-
Recombinant Protein
-
Related Products
应用
应用 | Ab评论 | 说明 |
---|---|---|
Sandwich ELISA |
Use a concentration of 0.5 - 2 µg/ml.
To detect Human TNF-α by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. |
说明 |
---|
Sandwich ELISA
Use a concentration of 0.5 - 2 µg/ml. To detect Human TNF-α by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. |
靶标
-
功能
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. -
疾病相关
Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). -
序列相似性
Belongs to the tumor necrosis factor family. -
翻译后修饰
The soluble form derives from the membrane form by proteolytic processing.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
-
别名
- APC1 antibody
- APC1 protein antibody
- Cachectin antibody
see all
数据表及文件
-
Datasheet download
文献 (52)
ab9635 被引用在 52 文献中.
- Qiao W et al. SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters. Nat Commun 13:2539 (2022). PubMed: 35534483
- Wang Z et al. Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model. Clin Exp Pharmacol Physiol 48:1090-1102 (2021). PubMed: 33638234
- Li X et al. IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17. Sci Rep 11:16378 (2021). PubMed: 34385542
- Liao S et al. Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury. Cell Death Discov 7:312 (2021). PubMed: 34689160
- Zhu J et al. MicroRNA-140-5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Exp Ther Med 21:171 (2021). PubMed: 33456538