Anti-Thyroglobulin抗体[5F9] (ab1984)

Submit a review Submit a question

Key features and details

  • Mouse monoclonal [5F9] to Thyroglobulin
  • Reacts with: Cow, Human
  • Isotype: IgG2a

概述

  • 产品名称

    Anti-Thyroglobulin抗体[5F9]
    参阅全部 Thyroglobulin 一抗

  • 描述

    小鼠单克隆抗体[5F9] to Thyroglobulin

  • 宿主

    Mouse

  • 特异性

    This antibody does not interfere with anti-thyroglobulin autoantibodies.

  • 种属反应性

    与反应: Cow, Human

  • 免疫原

    Thyroglobulin from human thyroid gland.

  • 常规说明

    Concentration varies from lot to lot and can be provided on request.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

靶标

  • 功能

    Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

  • 组织特异性

    Thyroid gland specific.

  • 疾病相关

    Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
    Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.

  • 序列相似性

    Belongs to the type-B carboxylesterase/lipase family.
    Contains 11 thyroglobulin type-1 domains.

  • 翻译后修饰

    Sulfated tyrosines are desulfated during iodination.

  • 细胞定位

    Secreted.
  • Information by UniProt

  • 数据库链接

    • 别名

      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    实验方案

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    文献 (0)

    发表研究结果有使用 ab1984？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab1984 尚未被引用在任何文献中。

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    There are currently no Customer reviews or Questions for ab1984.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com