Anti-Thyroglobulin抗体[5F9] (ab1984)
Key features and details
- Mouse monoclonal [5F9] to Thyroglobulin
- Reacts with: Cow, Human
- Isotype: IgG2a
概述
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产品名称
Anti-Thyroglobulin抗体[5F9]
参阅全部 Thyroglobulin 一抗 -
描述
小鼠单克隆抗体[5F9] to Thyroglobulin -
宿主
Mouse -
特异性
This antibody does not interfere with anti-thyroglobulin autoantibodies. -
种属反应性
与反应: Cow, Human -
免疫原
Thyroglobulin from human thyroid gland.
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常规说明
Concentration varies from lot to lot and can be provided on request.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.1% Sodium azide -
Concentration information loading... -
纯度
Protein G purified -
纯化说明
Purity is tested by electrophoresis. -
克隆
单克隆 -
克隆编号
5F9 -
骨髓瘤
Sp2/0 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
靶标
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功能
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). -
组织特异性
Thyroid gland specific. -
疾病相关
Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. -
序列相似性
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains. -
翻译后修饰
Sulfated tyrosines are desulfated during iodination. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 280706 Cow
- Entrez Gene: 7038 Human
- Omim: 188450 Human
- SwissProt: P01267 Cow
- SwissProt: P01266 Human
- Unigene: 654591 Human
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别名
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab1984 尚未被引用在任何文献中。