Anti-Thromboxane synthase抗体(ab39362)
Key features and details
- Rabbit polyclonal to Thromboxane synthase
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Thromboxane synthase抗体
参阅全部 Thromboxane synthase 一抗 -
描述
兔多克隆抗体to Thromboxane synthase -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Cynomolgus monkey -
免疫原
Synthetic peptide:
TNPDCQEKLLREVDVFKEK
, corresponding to amino acids 359/377 of Human Thromboxane synthase -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol, Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab39362 is an affinity purified IgG -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab39362于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa).
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说明 |
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WB
1/500. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa). |
靶标
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组织特异性
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. -
疾病相关
Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis. -
序列相似性
Belongs to the cytochrome P450 family. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 6916 Human
- Omim: 274180 Human
- SwissProt: Q2PG45 Cynomolgus monkey
- SwissProt: P24557 Human
- Unigene: 520757 Human
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别名
- BDPLT14 antibody
- CYP5 antibody
- CYP5A1 antibody
see all
图片
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All lanes : Anti-Thromboxane synthase antibody (ab39362) at 1 µg/ml
Lane 1 : Human spleen tissue lysate - total protein (ab29699)
Lane 2 : WI38 (Human lung fibroblast cell line) Whole Cell Lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 61 kDa
Observed band size: 54 kDa why is the actual band size different from the predicted?
Additional bands at: 21 kDa, 36 kDa. We are unsure as to the identity of these extra bands.
Exposure time: 8 minutes
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (9)
ab39362 被引用在 9 文献中.
- Pai CH et al. Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy. PLoS One 11:e0151617 (2016). IHC . PubMed: 26974824
- Walker MA et al. Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease. Atherosclerosis 246:98-105 (2016). PubMed: 26771386
- Font-Nieves M et al. Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes. J Biol Chem 287:6454-68 (2012). WB ; Mouse . PubMed: 22219191
- Chu LM et al. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Am J Physiol Heart Circ Physiol 302:H479-88 (2012). WB ; Pig . PubMed: 22037194
- Feng J et al. Thromboxane-induced contractile response of human coronary arterioles is diminished after cardioplegic arrest. Ann Thorac Surg 92:829-36 (2011). WB ; Human . PubMed: 21871266
- Carter PR et al. Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis. Inflamm Res 60:87-92 (2011). IHC-Fr ; Mouse . PubMed: 20694740
- Shoeb M et al. Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med 51:1686-96 (2011). WB ; Mouse . PubMed: 21856412
- Hansen AH et al. Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension. Hypertension 58:943-9 (2011). PubMed: 21896936
- Wright WS et al. Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina. Exp Eye Res 89:532-7 (2009). IHC-P ; Mouse, Rat . PubMed: 19523949