Anti-TGF beta 1抗体[TB21] (ab190503)
Key features and details
- Mouse monoclonal [TB21] to TGF beta 1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-TGF beta 1抗体[TB21]
参阅全部 TGF beta 1 一抗 -
描述
小鼠单克隆抗体[TB21] to TGF beta 1 -
宿主
Mouse -
特异性
ab190503 recognizes both human platelet-derived and recombinant TGF beta1 in enzyme-linked immunosorbent assay (ELISA). Mouse anti-Human TGF beta antibody, clone TB21 demonstrates neutralising activity against TGF beta1 in cell proliferation assays. Mouse anti Human TGF beta antibody, clone TB21 has been demonstrated to react with dimeric (25kD) or monomeric (12.5kD) molecules of natural TGF beta1 under non-reducing and reducing conditions respectively. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Horse, Guinea pig, Dog, Pig -
免疫原
Full length native protein (purified) corresponding to Human TGF beta 1 aa 250 to the C-terminus. purified from platelets.
Database link: P01137 -
阳性对照
- Human breast carcinoma and brain tissues.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
TB21 -
骨髓瘤
Sp2/0-Ag14 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab190503于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
ab190503 has been used successfully on FFPE tissues without pretreatment. Citrate pH6.0, EDTA pH8.0 or pepsin mediated antigen retrieval have also been used. |
说明 |
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IHC-P
Use at an assay dependent concentration. ab190503 has been used successfully on FFPE tissues without pretreatment. Citrate pH6.0, EDTA pH8.0 or pepsin mediated antigen retrieval have also been used. |
靶标
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功能
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. -
组织特异性
Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage. -
疾病相关
Defects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision. -
序列相似性
Belongs to the TGF-beta family. -
翻译后修饰
Glycosylated.
The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive. -
细胞定位
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 7040 Human
- Omim: 190180 Human
- SwissProt: P01137 Human
- Unigene: 645227 Human
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别名
- Cartilage-inducing factor antibody
- CED antibody
- Differentiation inhibiting factor antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (30)
ab190503 被引用在 30 文献中.
- Yu L et al. Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography. Asian J Androl 24:207-212 (2022). PubMed: 34494557
- Xiong G et al. Long non-coding RNA MEG3 regulates the progress of osteoarthritis by regulating the miR-34a/Klotho axis. Ann Transl Med 10:454 (2022). PubMed: 35571440
- Souza-Neto FV et al. Mitochondrial Oxidative Stress Promotes Cardiac Remodeling in Myocardial Infarction through the Activation of Endoplasmic Reticulum Stress. Antioxidants (Basel) 11:N/A (2022). PubMed: 35883722
- Leung D et al. Platinum-resistance in epithelial ovarian cancer: an interplay of epithelial-mesenchymal transition interlinked with reprogrammed metabolism. J Transl Med 20:556 (2022). PubMed: 36463238
- Kim IY et al. Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease. Korean J Intern Med 36:962-974 (2021). PubMed: 33322851