Anti-TCR V beta 5抗体[MEM-262] (ab1898)
Key features and details
- Mouse monoclonal [MEM-262] to TCR V beta 5
- Reacts with: Human
- Isotype: IgG2a
概述
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产品名称
Anti-TCR V beta 5抗体[MEM-262] -
描述
小鼠单克隆抗体[MEM-262] to TCR V beta 5 -
宿主
Mouse -
特异性
The antibody recognizes beta chains of the TCR expressed by HPB-ALL cell line [carrying V(beta5.3)] and a small subset of peripheral blood T cells. This subset is larger than that recognized by other V(beta5.3)-specific antibodies. -
种属反应性
与反应: Human -
免疫原
Human thymoma cell line HPB-ALL.
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常规说明
Functional Application Activates T cells (V beta 5-related subset).The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Purified from hybridoma culture supernatant. Purity >95% by SDS-PAGE. -
克隆
单克隆 -
克隆编号
MEM-262 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
靶标
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相关性
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. The Vß5 TCR is a variant of the TCR ß chain. It belongs to Ig superfamily and is expressed by a subset of peripheral blood T cells and some T cell clones. TCR Vß5 has been reported to recognize some staphylococcus bacterial superantigens. -
细胞定位
Cell Membrane -
数据库链接
- Entrez Gene: 28612 Human
- Omim: 186930 Human
- SwissProt: P03979 Human
- SwissProt: P04435 Human
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别名
- T cell receptor antibody
- TCB antibody
- TCRB antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab1898 被引用在 3 文献中.
- Wang CT et al. Attenuating systemic inflammatory markers in simulated high-altitude exposure by heat shock protein 70-mediated hypobaric hypoxia preconditioning in rats. J Formos Med Assoc 114:328-38 (2015). PubMed: 25839766
- Grabherr MG et al. Exploiting nucleotide composition to engineer promoters. PLoS One 6:e20136 (2011). PubMed: 21625601
- Pavlistová D et al. A novel monoclonal reagent recognizing native and denatured Vbeta5.3-related chains of human T cell receptor. Immunol Lett 88:105-8 (2003). PubMed: 12880678