ZRSR2
Function
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
Post-translational modifications
Phosphorylated in the RS domain by SRPK1.
Tissue Specificity
Widely expressed.
Cellular localization
- Nucleus
Alternative names
U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZRSR2, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, Renal carcinoma antigen NY-REN-20, U2(RNU2) small nuclear RNA auxiliary factor 1-like 2, U2AF35-related protein