ZC3HC1 phospho S354
Developmental stage
Weakly expressed in G0/G1 phases, abundant during S and G2/M phases, and strongly decreases thereafter.
Function
Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.
Post-translational modifications
Phosphorylated (PubMed:12748172). May also be weakly phosphorylated on Tyr residues (PubMed:12748172).
Tissue Specificity
Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.
Cellular localization
- Nucleus
- Nucleus envelope
- Resident of the nuclear basket (NB) (PubMed:34440706). Occurs at the nuclear envelopes (NE) of all TPR-containing cell types, including proliferating and non-dividing, terminally differentiated cells of different morphogenetic origin (PubMed:34440706).
Alternative names
NIPA, HSPC216, ZC3HC1, Zinc finger C3HC-type protein 1, Nuclear-interacting partner of ALK, Nuclear-interacting partner of anaplastic lymphoma kinase, hNIPA