Xcl1
Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Sequence Similarities
Belongs to the intercrine gamma family.
Tissue Specificity
Expressed in activated CD8(+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
Cellular localization
- Secreted
Alternative names
Lptn, Ltn, Scyc1, Xcl1, Lymphotactin, C motif chemokine 1, Cytokine SCM-1, Lymphotaxin, Small-inducible cytokine C1