WDR3
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Sequence Similarities
Belongs to the WD repeat WDR3/UTP12 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
- Nucleolus
Alternative names
WD repeat-containing protein 3, WDR3