WDR18
Function
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity).
Sequence Similarities
Belongs to the WD repeat IPI3/WDR18 family.
Cellular localization
- Nucleus
- Nucleolus
- Nucleus
- Nucleoplasm
- Cytoplasm
- Dynein axonemal particle
- Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
Alternative names
WD repeat-containing protein 18, WDR18