WASF2
Domain
Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Sequence Similarities
Belongs to the SCAR/WAVE family.
Tissue Specificity
Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Lamellipodium
- Basolateral cell membrane
- At the interface between the lamellipodial actin meshwork and the membrane.
Alternative names
WAVE2, WASF2, Actin-binding protein WASF2, Protein WAVE-2, Verprolin homology domain-containing protein 2, Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2