UBLCP1
Domain
The Ubiquitin-like domain mediates interaction with proteasomes.
Function
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity (PubMed:21949367, PubMed:28539385). Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1 (PubMed:28539385). Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385). Has also been reported to stimulate the proteolytic activity of the 26S proteasome (PubMed:32071216).
Tissue Specificity
Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues.
Cellular localization
- Nucleus
- Colocalizes with nuclear proteasomes.
Alternative names
Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, UBLCP1