TXNDC17
Function
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
Post-translational modifications
The oxidized protein is reduced by TRXR1.
Sequence Similarities
Belongs to the thioredoxin family.
Tissue Specificity
Ubiquitously expressed in cell lines.
Cellular localization
- Cytoplasm
Alternative names
TXNL5, TXNDC17, Thioredoxin domain-containing protein 17, 14 kDa thioredoxin-related protein, Protein 42-9-9, Thioredoxin-like protein 5, TRP14