TRIM35
Domain
The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.
Function
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway (PubMed:32562145). Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2 (PubMed:32562145). Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway (PubMed:25907537). Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439).
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the TRIM/RBCC family.
Cellular localization
- Cytoplasm
- Nucleus
- Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity).
Alternative names
HLS5, KIAA1098, TRIM35, E3 ubiquitin-protein ligase TRIM35, Hemopoietic lineage switch protein 5