TNFRSF17
GeneName
TNFRSF17
Summary
TNFRSF17, commonly known as BCMA (B-cell maturation antigen), is a 20 kDa transmembrane protein predominantly expressed on the surface of B cells and plasma cells. It is localised to the plasma membrane and plays a crucial role in the adaptive immune response by mediating signal transduction through its interaction with tumour necrosis factor (TNF) family ligands. BCMA is involved in lymphocyte homeostasis and is essential for the survival and differentiation of B cells, particularly in the context of antibody production and immune regulation.
Importance
BCMA is relevant to: - Multiple myeloma therapy as a target for monoclonal antibodies and CAR T-cell therapies due to its overexpression in malignant plasma cells - Understanding B cell biology and the mechanisms of immune response, which can inform vaccine development and autoimmune disease treatments - Investigating the role of BCMA in lymphocyte homeostasis, providing insights into B cell development and function - Exploring its involvement in the TNF-mediated signalling pathways, which are critical in various inflammatory and autoimmune conditions
Top Products
For researchers investigating TNFRSF17, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-BCMA antibody - C-terminal (ab5972), which has garnered 12 citations and is highly regarded for its performance in immunohistochemistry (IHC), western blotting (WB), and immunocytochemistry (ICC). This antibody is a trusted choice for those requiring reliable detection of TNFRSF17 in various applications. Additionally, we offer the recombinant antibody, Anti-BCMA antibody [EPR22457-260] (ab253242), which is suitable for flow cytometry (FC), WB, ICC, and immunoprecipitation (IP). With 2 citations, this recombinant product provides the batch-to-batch consistency that researchers often seek. Together, these antibodies provide a comprehensive toolkit for studying TNFRSF17 effectively. "The Human BCMA ELISA Kit (ab263875), supported by 2 citations, is an excellent option for researchers looking to measure TNFRSF17 levels in their samples."
Abcam Product Citation Summary
The data indicates that TNFRSF17 is being investigated in the context of systemic lupus erythematosus, highlighting its potential role in autoimmune diseases. The use of Abcam antibody ab213840 in human subjects suggests a focus on understanding the implications of TNFRSF17 in this condition.
Abcam Product Citation Table
Function
The protein expressed by the TNFRSF17 gene acts as a receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. It promotes B-cell survival and plays a role in regulating humoral immunity, while also activating NF-kappa-B and JNK. This supplementary information is collated from multiple sources and compiled automatically.
Involvement in disease
A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Tissue Specificity
Expressed in mature B-cells, but not in T-cells or monocytes.
Cellular localization
- Cell membrane
- Single-pass type III membrane protein
- Endomembrane system
- Single-pass type III membrane protein
- Perinuclear Golgi-like structures.
Alternative names
CD269, BCM, BCMA, TNFRSF17, Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein