TNC
GeneName
TNC
Summary
TNC, also known as tenascin C, is a 241 kDa extracellular matrix protein that plays a pivotal role in cell adhesion and tissue architecture. It is predominantly found in the extracellular matrix, particularly within the basement membrane and interstitial matrix, and is involved in various biological processes such as lung branching, neuromuscular junction development, and osteoblast differentiation. TNC interacts with integrins and syndecans, contributing to cellular responses to stimuli like retinoic acid and vitamin D, and is implicated in morphogenetic processes and the regulation of cell migration and growth.
Importance
TNC is relevant to: - Tissue repair and regeneration due to its role in cell adhesion and migration - Cancer biology, as it is associated with tumour progression and metastasis - Neurodevelopmental processes, particularly in the context of peripheral nervous system axon regeneration - Inflammatory responses and conditions, given its regulatory role in cell adhesion and inflammatory pathways
Top Products
For researchers investigating Tenascin C (TNC), we highly recommend the Anti-Tenascin C antibody [EPR4219] (ab108930). This top-selling recombinant antibody has been validated in knockout models, ensuring reliable performance in your experiments. It is particularly effective for immunohistochemistry (IHC) and western blotting (WB), making it a versatile choice for various applications. With 120 citations, this antibody is well-regarded in the research community, reflecting its trustworthiness and efficacy in TNC studies. "The Human Tenascin C ELISA Kit (ab277081) is a reliable option for researchers looking to measure Tenascin C in their samples."
Abcam Product Citation Summary
The data indicates that TNC antibodies are extensively used in various studies related to glioma, lung tissue, and muscle stem cell proliferation. The majority of the experiments were conducted using mouse and human samples, highlighting the relevance of TNC in cancer research and developmental biology.
Abcam Product Citation Table
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Involvement in disease
Deafness, autosomal dominant, 56
DFNA56
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the tenascin family.
Tissue Specificity
Detected in fibroblasts (at protein level).
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
HXB, TNC, Tenascin, TN, Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, JI, Myotendinous antigen, Neuronectin, Tenascin-C, TN-C