TLR10
Function
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Sequence Similarities
Belongs to the Toll-like receptor family.
Tissue Specificity
Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD290, UNQ315/PRO358, TLR10, Toll-like receptor 10