THY1

GeneName

THY1

Summary

THY1, also known as Thy-1 or CD90, is an 18 kDa glycosylphosphatidylinositol (GPI)-anchored membrane protein primarily expressed on the surface of T cells, neurons, and various other cell types. It is localised to several cellular components including the plasma membrane, dendrites, and focal adhesions. THY1 plays a significant role in cell-cell adhesion and signalling, influencing processes such as angiogenesis and cytoskeleton organisation. Its interactions with integrins and other proteins facilitate important cellular functions, including T cell activation and the regulation of cell migration.

Importance

THY1 is relevant to: - T cell biology and immunology, particularly in the context of T cell activation and signalling pathways - Neurobiology, as it is involved in neuronal development and synaptic functions - Angiogenesis and tissue repair, given its role in cell adhesion and migration - Cancer research, where it may influence tumour microenvironment interactions and immune evasion strategies

Top Products

For researchers investigating THY1, we recommend two excellent primary antibodies that have garnered significant attention in the field. The first is the well-cited Anti-CD90 / Thy1 antibody [EPR3133] (ab133350), which has been validated in knockout models and is suitable for immunocytochemistry (ICC), immunohistochemistry (IHC), and western blotting (WB). With 82 citations, this antibody is a trusted choice among researchers. Additionally, we offer the recombinant antibody, Anti-CD90 / Thy1 antibody [EPR3132] (ab92574), which is also validated in knockout models and is effective for IHC and WB applications. This recombinant option has 76 citations, showcasing its reliability and performance. Both antibodies provide robust tools for studying THY1, catering to various experimental needs while ensuring consistency and reliability in your research.

Abcam Product Citation Summary

The data indicates that THY1 is being studied in various human contexts, including adipose-derived mesenchymal stem cells, lung spheroids, and gastric cancer tissues. The use of multiple applications such as flow cytometry, Western blotting, and immunocytochemistry highlights the importance of THY1 in different biological processes and disease states, particularly in cancer and stem cell research.