THSD7A
Domain
Sequence analysis combined with the expression of constructs corresponding each to two or three adjacent TSP type-1 domains suggests the presence of 21 TSP type-1 domains; not all of these are detected by standard bioinformatic tools.
Function
Thrombospondin type-1 domain-containing protein 7A
Plays a role in actin cytoskeleton rearrangement.
Thrombospondin type-1 domain-containing protein 7A, soluble form
The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
Involvement in disease
Autoantibodies against THSD7A have been detected in serum and glomeruli from patients with idiopathic membranous nephropathy (PubMed:25394321). The majority of the autoantibodies react with the two most N-terminal TSP type-1 domains (PubMed:29555830).
Post-translational modifications
Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.
Extensively N-glycosylated.
Tissue Specificity
Detected on kidney podocytes along the glomerular capillary wall (at protein level).
Cellular localization
- Thrombospondin type-1 domain-containing protein 7A
- Cell membrane
- Single-pass type I membrane protein
- Cell projection
- Detected on podocyte foot processes.
- Thrombospondin type-1 domain-containing protein 7A, soluble form
- Secreted
- Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.
Alternative names
KIAA0960, THSD7A, Thrombospondin type-1 domain-containing protein 7A