TFPI2
Domain
This inhibitor contains three inhibitory domains.
Function
May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
Tissue Specificity
Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
Cellular localization
- Secreted
Alternative names
Tissue factor pathway inhibitor 2, TFPI-2, Placental protein 5, PP5, TFPI2