TFPI
Domain
This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
Function
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Post-translational modifications
O-glycosylated.
Tissue Specificity
Mostly in endothelial cells.
Cellular localization
- Isoform Alpha
- Secreted
- Isoform Beta
- Microsome membrane
- Lipid-anchor
- GPI-anchor
Alternative names
LACI, TFPI1, TFPI, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, Lipoprotein-associated coagulation inhibitor, EPI