SSX2

Function

Could act as a modulator of transcription.

Involvement in disease

A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Sequence Similarities

Belongs to the SSX family.

Tissue Specificity

Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.

Cellular localization

• Nucleus

Alternative names

SSX2A, SSX2B, SSX2, Protein SSX2, Cancer/testis antigen 5.2, Tumor antigen HOM-MEL-40, CT5.2

Database links

swissprot:Q16385 entrezGene:727837 entrezGene:6757 omim:300192