SEC23B
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Involvement in disease
Cowden syndrome 7
CWS7
A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. CWS7 inheritance is autosomal dominant.
None
The disease is caused by variants affecting the gene represented in this entry.
Anemia, congenital dyserythropoietic, 2
CDAN2
An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, normocytic anemia, iron overload, jaundice, and variable splenomegaly. Ultrastructural features include bi- or multinucleated erythroblasts in bone marrow, karyorrhexis, and the presence of Gaucher-like bone marrow histiocytes. The main biochemical feature of the disease is defective glycosylation of some red blood cells membrane proteins.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Cytoplasmic vesicle
- COPII-coated vesicle membrane
- Peripheral membrane protein
- Cytoplasmic side
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Cytosol
Alternative names
Protein transport protein Sec23B, hSec23B, SEC23-related protein B, SEC23B