SEC22B
Function
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Sequence Similarities
Belongs to the synaptobrevin family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Endoplasmic reticulum-Golgi intermediate compartment membrane
- Golgi apparatus
- cis-Golgi network membrane
- Golgi apparatus
- trans-Golgi network membrane
- Melanosome
- Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Alternative names
SEC22L1, SEC22B, Vesicle-trafficking protein SEC22b, ER-Golgi SNARE of 24 kDa, SEC22 vesicle-trafficking protein homolog B, SEC22 vesicle-trafficking protein-like 1, ERS-24, ERS24