RPS3A
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).
Post-translational modifications
ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.
Sequence Similarities
Belongs to the eukaryotic ribosomal protein eS1 family.
Cellular localization
- Cytoplasm
- Nucleus
- Nucleus
- Nucleolus
- Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Alternative names
FTE1, MFTL, RPS3A, Small ribosomal subunit protein eS1, 40S ribosomal protein S3a, v-fos transformation effector protein, Fte-1