Rph3a
Domain
Binds calcium via the C2 domains. The calcium-bound C2 domains mediate interactions with phospholipid bilayers.
Function
Plays an essential role in docking and fusion steps of regulated exocytosis (PubMed:16203731, PubMed:8617225). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (PubMed:8617225). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability (PubMed:26679993). Also plays a role in the exocytosis of arginine vasopressin hormone (PubMed:29367474).
Post-translational modifications
Ubiquitinated. Deubiquitinated by CAND1 to prevent its degradation.
Tissue Specificity
Specifically expressed in brain.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Cell projection
- Dendritic spine
- Postsynaptic cell membrane
- Membrane
- Peripheral membrane protein
Alternative names
Rabphilin-3A, Exophilin-1