RHOT2
Function
Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16630562, PubMed:22396657). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:22396657).
Post-translational modifications
Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.
Sequence Similarities
Belongs to the mitochondrial Rho GTPase family.
Tissue Specificity
Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.
Cellular localization
- Mitochondrion outer membrane
- Single-pass type IV membrane protein
- Colocalizes with MGARP and RHOT2 at the mitochondria.
Alternative names
ARHT2, C16orf39, RHOT2, Mitochondrial Rho GTPase 2, MIRO-2, hMiro-2, Ras homolog gene family member T2