RHOC

Function

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.

Post-translational modifications

(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.

(Microbial infection) Glucosylated at Thr-37 by C.difficile toxins TcdA and TcdB in the colonic epithelium (PubMed:24905543). Monoglucosylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to actin cytoskeleton disruption (PubMed:24905543).

Sequence Similarities

Belongs to the small GTPase superfamily. Rho family.

Cellular localization

• Cell membrane
• Lipid-anchor
• Cytoplasmic side
• Cleavage furrow
• Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Alternative names

ARH9, ARHC, RHOC, Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9

Database links

swissprot:P08134 entrezGene:388 entrezGene:389 entrezGene:387 omim:165370 swissprot:P61586 omim:165380 omim:165390 swissprot:P62745