RBBP9
Function
Serine hydrolase whose substrates have not been identified yet (PubMed:19329999, PubMed:20080647). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699).
Sequence Similarities
Belongs to the RBBP9 family.
Tissue Specificity
Expressed at higher levels in tumor tissues such as carcinoma.
Alternative names
BOG, RBBP10, RBBP9, Serine hydrolase RBBP9, B5T-overexpressed gene protein, Retinoblastoma-binding protein 10, Retinoblastoma-binding protein 9, Protein BOG, RBBP-10, RBBP-9