Ptprc
Domain
The first PTPase domain interacts with SKAP1.
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Post-translational modifications
Heavily N- and O-glycosylated.
The cytoplasmic domain contains potential phosphorylation sites.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Tissue Specificity
Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Membrane raft
- Synapse
- Colocalized with DPP4 in membrane rafts.
Alternative names
CD45, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, L-CA, Ptprc