PTPRA phospho Y798
Function
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
Post-translational modifications
Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- Focal adhesion
- Localizes to focal adhesion sites following integrin engagement.
Alternative names
PTPA, PTPRL2, PTPRA, Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha