PTGES3
Domain
The PXLE motif mediates interaction with EGLN1/PHD2.
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Post-translational modifications
Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation.
Sequence Similarities
Belongs to the p23/wos2 family.
Cellular localization
- Cytoplasm
Alternative names
P23, TEBP, PTGES3, Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, cPGES