PRAME
Function
The protein expressed by gene PRAME functions as a transcriptional repressor, inhibiting retinoic acid signaling through retinoic acid receptors RARA, RARB, and RARG. It prevents retinoic acid-induced cell proliferation arrest, differentiation, and apoptosis. This supplementary information is collated from multiple sources and compiled automatically.
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the PRAME family.
Tissue Specificity
Expressed in testis. Detected in samples of kidney, brain and skin.
Cellular localization
- Nucleus
- Chromosome
- Cytoplasm
- Golgi apparatus
- Cell membrane
- Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923).
Alternative names
MAPE, OIP4, PRAME, Melanoma antigen preferentially expressed in tumors, Opa-interacting protein 4, Preferentially expressed antigen of melanoma, OIP-4