PDLIM2
Function
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Cellular localization
- Cytoplasm
- Nucleus
- May be partially nuclear.
- Isoform 1
- Cytoplasm
- Cytoskeleton
- Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
- Isoform 2
- Cytoplasm
- Cytoskeleton
- Isoform 3
- Nucleus
Alternative names
PP6345, PDLIM2, PDZ and LIM domain protein 2, PDZ-LIM protein mystique