NUMB

Function

Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).

Post-translational modifications

Phosphorylated on Ser-276 and Ser-295 by CaMK1.

Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Cellular localization

• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Endosome membrane
• Peripheral membrane protein
• Cytoplasmic side
• Localizes to perinuclear endosomes in an AAK1-dependent manner.

Alternative names

C14orf41, NUMB, Protein numb homolog, h-Numb, Protein S171

Database links

swissprot:P49757 entrezGene:8650 omim:603728

Other research areas

• Neuroscience