NGF
GeneName
NGF
Summary
NGF, also known as nerve growth factor, beta NGF, or beta nerve growth factor, is a 27 kDa secreted protein that plays a crucial role in the growth, maintenance, and survival of neurons. It is primarily expressed in the extracellular space and is involved in various cellular processes such as axon extension and neuron differentiation. NGF binds to its high-affinity receptor, TrkA, activating signalling pathways that promote neuronal survival and development. It is also implicated in modulating synaptic transmission and has roles in apoptotic signalling pathways, influencing both neuron maturation and the regulation of neurotransmitter secretion.
Importance
NGF is relevant to: - Neurodevelopmental research due to its essential role in neuronal growth and survival - Pain mechanisms, as it is involved in the sensory perception of pain and can influence pain pathways - Neurodegenerative diseases, where its modulation of neuronal health may provide insights into therapeutic strategies - Regenerative medicine, particularly in strategies aimed at enhancing nerve repair and regeneration following injury
Top Products
For researchers investigating NGF, we highly recommend the top-selling recombinant antibody, Anti-NGF antibody [EP1320Y] (ab52918). This antibody has been validated for use in Western blotting (WB) and immunocytochemistry (ICC), making it a versatile tool for various experimental setups. With 121 citations, it is well-regarded in the research community, reflecting its reliability and effectiveness in NGF studies. This recombinant antibody ensures batch-to-batch consistency, providing confidence in your experimental results. The Human beta Nerve Growth Factor ELISA Kit (ab193760), supported by 7 citations, is an excellent option for researchers looking to accurately measure NGF levels in their samples.
Abcam Product Citation Summary
The data indicates that NGF is being extensively studied in various contexts, particularly in relation to pancreatic cancer and neuroinflammation. The use of Abcam antibodies in both Western blotting and immunohistochemistry highlights the importance of NGF in understanding tumour biology and neuroregenerative processes. The studies span across different species, including human and rat models, suggesting a broad interest in the role of NGF in both cancer and nerve regeneration.
Abcam Product Citation Table
Function
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable) (PubMed:20978020). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
Involvement in disease
Neuropathy, hereditary sensory and autonomic, 5
HSAN5
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the NGF-beta family.
Cellular localization
- Secreted
- Endosome lumen
- ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR.
Alternative names
NGFB, NGF, Beta-nerve growth factor, Beta-NGF