Ncam1

Function

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

Post-translational modifications

Polysialylated by ST8SIA2 and ST8SIA4. Polysialylation modulates cell interactions by confering both attractive and repulsive properties that are highly regulated by ST8SIA2 and ST8SIA4. Polysialylation is formed on a-2,3-linked sialic acid of core glycans.

Cellular localization

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Cell membrane
• Single-pass type I membrane protein
• Isoform 3
• Cell membrane
• Lipid-anchor
• GPI-anchor

Alternative names

CD56, Ncam, Ncam1, Neural cell adhesion molecule 1, N-CAM-1, NCAM-1

Database links

swissprot:P13595 entrezGene:17967

Other research areas

• Immuno-oncology
• Neuroscience